Publications

 

2017

1. Debrah LB, Nausch N, Opoku VS, Owusu W, Mubarik Y, Berko DA, Wanji S, Layland LE, Hoerauf A, Jacobsen M, Debrah AY, Phillips RO. Epidemiology of Mansonella perstans in the middle belt of Ghana. Parasit Vectors. 2017 Jan 7;10(1)

2. Klarmann-Schulz U, Specht S, Debrah AY, Batsa L, Ayisi-Boateng NK, Osei-Mensah J, Mubarik Y, Konadu P, Ricchiuto A, Fimmers R, Arriens S, Dubben B, Ford L, Taylor M, Hoerauf A. Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial. PLoS Negl Trop Dis. 2017 Jan 5;11(1)

3. Hirschfeld J, Akinoglu EM, Wirtz DC, Hoerauf A, Bekeredjian-Ding I, Jepsen S, Haddouti EM, Limmer A, Giersig M. Long-term release of antibiotics by carbon nanotube-coated titanium alloy surfaces diminish biofilm formation by Staphylococcus epidermidis. Nanomedicine. 2017 Jan 20. pii: S1549-9634(17)30004-7.

4. Uebele J, Stein C, Nguyen MT, Schneider A, Kleinert F, Tichá¡ O, Bierbaum G, Götz F, Bekeredjian-Ding I. Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus. PLoS Pathog. 2017 May 25;13(5):e1006387.

5. Hilbert T, Steinhagen F, Senzig S, Cramer N, Bekeredjian-Ding I, Parcina M, Baumgarten G, Hoeft A, Frede S, Boehm O, Klaschik S. Vendor effects on murine gut microbiota influence experimental abdominal sepsis. J Surg Res. 2017 May 1;211:126-136.

6. Kleinert F, Kallies R, Hort M, Zweynert A, Szekat C, Nagel M, Bierbaum G. Influence of IS256 on genome variability and formation of SCV in Staphylococcus aureus. Antimicrob Agents Chemother. 2017 Jun 5. pii: AAC.00144-17.

7. Globisch D, Eubanks LM, Shirey RJ, Pfarr KM, Wanji S, Debrah AY, Hoerauf A, Janda KD. Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide(NATOG).
Bioorg Med Chem Lett. 2017 May 29. pii: S0960-894X(17)30581-4.

8. Lutz P, Goeser F, Kaczmarek DJ, Schlabe S, Nischalke HD, Nattermann J, Hoerauf A, Strassburg CP, Spengler U. Relative Ascites Polymorphonuclear Cell Count Indicates Bacterascites and Risk of Spontaneous Bacterial Peritonitis. Dig Dis
Sci. 2017 Jun 9.

9. Maffioli SI, Zhang Y, Degen D, Carzaniga T, Del Gatto G, Serina S, Monciardini P, Mazzetti C, Guglierame P, Candiani G, Chiriac AI, Facchetti G, Kaltofen P, Sahl HG, Dehò² G, Donadio S, Ebright RH. Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell. 2017 Jun 15;169(7):1240-1248.e23.

10. Nair DR, Chen J, Monteiro JM, Josten M, Pinho MG, Sahl HG, Wu J, Cheung A. A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism. J Antibiot (Tokyo). 2017 Jul 12.

11. Prodjinotho UF, von Horn C, Debrah AY, Batsa Debrah L, Albers A, Layland LE, Hoerauf A, Adjobimey T. Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes. PLoS Negl Trop Dis. 2017 Jul 24;11(7)

12. Hirschfeld J, Howait M, Movila A, Parcina M, Bekeredjian-Ding I, Deschner J, Jepsen S, Kawai T. Assessment of the involvement of the macrophage migration inhibitory factor-glucocorticoid regulatory dyad in the expression of matrix metalloproteinase-2 during periodontitis. Eur J Oral Sci. 2017 Aug 4.

13. Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E. RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection. Mol Ther. 2017 Jul 8. pii: S1525-0016(17)30317-9.

14. Wewer V, Makepeace BL, Tanya VN, Peisker H, Pfarr K, Hoerauf A, Dörmann P. Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host. Int J Parasitol. 2017 Jul 23. pii: S0020-7519(17)30205-9.

15. Schüller A, Matzner D, Lünse CE, Wittmann V, Schumacher C, Unsleber S, Brötz-Oesterhelt H, Mayer C, Bierbaum G, Mayer G. Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition. Chembiochem. 2017 Mar 2;18(5):435-440.

16. Wilmes M, Meier K, Schiefer A, Josten M, Otten CF, Klöckner A, Henrichfreise B, Vollmer W, Hoerauf A, Pfarr K. AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster. Front Cell Infect Microbiol. 2017 Aug 4;7:353.

17. Ritter M, Tamadaho RSE, Feid J, Vogel W, Wiszniewsky K, Perner S, Hoerauf A, Layland LE. IL-4/5 signalling plays an important role during Litomosoides sigmodontis infection, influencing both immune system regulation and tissue pathology in the thoracic cavity. Int J Parasitol. 2017 Aug 28. pii:
S0020-7519(17)30230-8.

18. Njouendou AJ, Ritter M, Ndongmo WPC, Kien CA, Narcisse GTV, Fombad FF, Tayong DB, Pfarr K, Layland LE, Hoerauf A, Wanji S. Successful long-term maintenance of Mansonella perstans in an in vitro culture system. Parasit Vectors. 2017 Nov 10;10(1):563.

19. Debrah LB, Albers A, Debrah AY, Brockschmidt FF, Becker T, Herold C, Hofmann A, Osei-Mensah J, Mubarik Y, Fröhlich H, Hoerauf A, Pfarr K. Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with  lymphedema caused by Wuchereria bancrofti. Hum Genomics. 2017 Nov 9;11(1):26.

20. Froeschen F, Gajdiss M, Uebele J, Meilaender A, Hoerauf A, Exner M, Molitor E, Bierbaum G, Engelhart S, Bekeredjian-Ding I. Rapid monitoring of local epidemiology of vancomycin-resistant Enterococcus faecium on a department level by repPCR. J Hosp Infect. 2017 Dec 1. pii: S0195-6701(17)30644-8.

2016

 

1. A Elnakady Y, Chatterjee I, Bischoff M, Rohde M, Josten M, Sahl HG, Herrmann M, Müller R. Investigations to the Antibacterial Mechanism of Action of Kendomycin. PLoS One. 2016 Jan 21;11(1)

2. Grass G, Bierbaum G, Molitor E, Götte N, Antwerpen M. Genome Sequence of Bacillus pumilus Strain Bonn, Isolated from an Anthrax-Like Necrotic Skin Infection Site of a Child. Genome Announc. 2016 Feb 11;4(1).

3. Waller T, Kesper L, Hirschfeld J, Dommisch H, Kölpin J, Oldenburg J, Uebele J, Hoerauf A, Deschner J, Jepsen S, Bekeredjian-Ding I. Porphyromonas gingivalis outer membrane vesicles induce selective TNF tolerance in a TLR4- and mTOR-dependent manner. Infect Immun. 2016 Feb 8.

4. Ajendra J, Berbudi A, Hoerauf A, Hübner MP. Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis.. Clin Immunol. 2016 Feb 16.

5. Kajula M, Ward JM, Turpeinen A, Tejesvi MV, Hokkanen J, Tolonen A, Häkkänen H, Picart P, Ihalainen J, Sahl HG, Pirttilä AM, Mattila S. Bridged Epipolythiodiketopiperazines from Penicillium raciborskii, an Endophytic Fungus of Rhododendron tomentosum Harmaja. J Nat Prod. 2016 Apr 8.

6. Nguyen MT, Kraft B, Yu W, Demircioglu DD, Hertlein T, Burian M, Schmaler M, Boller K, Bekeredjian-Ding I, Ohlsen K, Schittek B, Götz F. The VSa alpha Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells. PLoS Pathog. 2015 Jun 17;11(6)

7. Sahl HG, Shai Y. Bacterial resistance to antimicrobial peptides. Biochim Biophys Acta. 2015 Nov;1848(11 Pt B):3019-20.

8. Münch D, Sahl HG. Structural variations of the cell wall precursor lipid II in Gram-positive bacteria - Impact on binding and efficacy of antimicrobial peptides. Biochim Biophys Acta. 2015 Nov;1848(11 Pt B):3062-71.

9. Kroidl I, Saathof E, Maganga L, Clowes P, Maboko L, Hoerauf A, Makunde WH, Haule A, Mviombo P, Pitter B, Mgeni N, Mabuye J, Kowuor D, Mwingira U, Malecela MN, Löscher T, Hoelscher M. Prevalence of Lymphatic Filariasis and Treatment Effectiveness of Albendazole/ Ivermectin in Individuals with HIV Co-infection in Southwest-Tanzania. PLoS Negl Trop Dis. 2016 Apr 12;10(4):e0004618.

10. Debrah AY, Specht S, Klarmann-Schulz U, Batsa L, Mand S, Marfo-Debrekyei Y, Fimmers R, Dubben B, Kwarteng A, Osei-Atweneboana M, Boakye D, Ricchiuto A, Büttner M, Adjei O, Mackenzie CD, Hoerauf A. Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial. Clin Infect Dis. 2015 Aug 15;61(4):517-26.

11. Elfaki TE, Arndts K, Wiszniewsky A, Ritter M, Goreish IA, Atti El Mekki Mel Y, Arriens S, Pfarr K, Fimmers R, Doenhoff M, Hoerauf A, Layland LE. Multivariable Regression Analysis in Schistosoma mansoni-Infected Individuals in the Sudan Reveals Unique Immunoepidemiological Profiles in Uninfected, egg+ and Non-egg+ Infected Individuals. PLoS Negl Trop Dis. 2016 May 6;10(5):e0004629.

12. Maffioli SI, Monciardini P, Catacchio B, Mazzetti C, Münch D, Brunati C, Sahl HG, Donadio S. Family of class I lantibiotics from actinomycetes and improvement of their antibacterial activities. ACS Chem Biol. 2015 Apr 17;10(4):1034-42.

13. Colebunders R, Mandro M, Mokili JL, Mucinya G, Mambandu G, Pfarr K, Reiter-Owona I, Hoerauf A, Tepage F, Levick B, Begon M, Laudisoit A. Risk factors for epilepsy in the Bas-Uele Province in the Democratic Republic of the Congo: a  case control study. Int J Infect Dis. 2016 May 19. pii: S1201-9712(16)31061-X.

14. Wanji S, Tayong DB, Layland LE, Datchoua Poutcheu FR, Ndongmo WP, Kengne-Ouafo JA, Ritter M, Amvongo-Adjia N, Fombad FF, Njeshi CN, Nkwescheu AS, Enyong PA, Hoerauf A. Update on the distribution of Mansonella perstans in the southern part of Cameroon: influence of ecological factors and mass drug administration with ivermectin. Parasit Vectors. 2016 May 31;9(1):311.

15. Henrich E, Ma Y, Engels I, Münch D, Otten C, Schneider T, Henrichfreise B, Sahl HG, Dötsch V, Bernhard F. Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway. J Biol Chem. 2016 Jan 29;291(5):2535-46.

16. Kroidl I, Saathoff E, Maganga L, Makunde WH, Hoerauf A, Geldmacher C, Clowes P, Maboko L, Hoelscher M. Effect of Wuchereria bancrofti infection on HIV incidence in southwest Tanzania: a prospective cohort study. Lancet. 2016 Aug 3.

17. Lutz P, Pfarr K, Nischalke HD, Krämer B, Goeser F, Glässner A, Wolter F, Kokordelis P, Nattermann J, Sauerbruch T, Hoerauf A, Strassburg CP, Spengler U. The ratio of calprotectin to total protein as a diagnostic and prognostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites. Clin Chem Lab Med. 2015 Nov;53(12):2031-9.

18. Kleinert F, Kallies R, Zweynert A, Bierbaum G. Draft Genome Sequences of Three Northern German Epidemic Staphylococcus aureus (ST247) Strains Containing Multiple Copies of IS256. Genome Announc. 2016 Sep 8;4(5).

19. Tejesvi MV, Picart P, Kajula M, Hautajärvi H, Ruddock L, Kristensen HH, Tossi A, Sahl HG, Ek S, Mattila S, Pirttilä AM. Identification of antibacterial peptides from endophytic microbiome. Appl Microbiol Biotechnol. 2016 Aug 19.

20. El-Jade MR, Parcina M, Schmithausen RM, Stein C, Meilaender A, Hoerauf A, Molitor E, Bekeredjian-Ding I. ESBL Detection: Comparison of a Commercially Available Chromogenic Test for Third Generation Cephalosporine Resistance and Automated Susceptibility Testing in Enterobactericeae. PLoS One. 2016 Aug 5;11(8):e0160203.

21. Alferink J, Specht S, Arends H, Schumak B, Schmidt K, Ruland C, Lundt R, Kemter A, Dlugos A, Kuepper JM, Poppensieker K, Findeiss M, Albayram Ö, Otte DM, Marazzi J, Gertsch J, Förster I, Maier W, Scheu S, Hoerauf A, Zimmer A. Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism. J Biol Chem. 2016 Sep 9;291(37):19517-31.

22. Müller A, Wenzel M, Strahl H, Grein F, Saaki TN, Kohl B, Siersma T, Bandow JE, Sahl HG, Schneider T, Hamoen LW. Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains. Proc Natl Acad Sci U S A. 2016 Oct 24.

23. Berbudi A, Surendar J, Ajendra J, Gondorf F, Schmidt D, Neumann AL, Wardani AP, Layland LE, Hoffmann LS, Pfeifer A, Hoerauf A, Hübner MP. Filarial Infection or Antigen Administration Improves Glucose Tolerance in Diet-Induced Obese Mice. J Innate Immun. 2016;8(6):601-616.

24. Surendar J, Indulekha K, Hoerauf A, Hübner MP. Immunomodulation by helminths: similar impact on type 1 and type 2 diabetes? Parasite Immunol. 2016 Nov 10.
 

25. Lutz P, Nischalke HD, Krämer B, Goeser F, Kaczmarek DJ, Schlabe S, Parcina M, Nattermann J, Hoerauf A, Strassburg CP, Spengler U. Antibiotic resistance in healthcare-related and nosocomial spontaneous bacterial peritonitis. Eur J Clin
Invest. 2016 Nov 15.

26. Gajdiss M, Türck M, Bierbaum G. Bacterial Histidine Kinases: Overexpression, Purification, and Inhibitor Screen. Methods Mol Biol. 2017;1520:247-259.

27. Wilmes M, Sahl HG. Determination of Bacterial Membrane Impairment by Antimicrobial Agents. Methods Mol Biol. 2017;1520:133-143.

28. Schuster D, Rickmeyer J, Gajdiss M, Thye T, Lorenzen S, Reif M, Josten M, Szekat C, Melo LD, Schmithausen RM, Liegeois F, Sahl HG, Gonzalez JJ, Nagel M, Bierbaum G. Differentiation of Staphylococcus argenteus (formerly: Staphylococcus aureus clonal complex 75) by mass spectrometry from S. aureus using the first strain isolated from a wild African great ape. Int J Med Microbiol. 2016 Nov 30. 

29. Ajendra J, Specht S, Ziewer S, Schiefer A, Pfarr K, Parcina M, Kufer TA, Hoerauf A, Hübner MP. NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae. Sci Rep. 2016 Dec 22;6:39648.

30. Hardt P, Engels I, Rausch M, Gajdiss M, Ulm H, Sass P, Ohlsen K, Sahl HG, Bierbaum G, Schneider T, Grein F. The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus. Int J Med Microbiol. 2016 Dec 12.

31. Raafat D, Leib N, Wilmes M, Francois P, Schrenzel J, Sahl HG. Development of in vitro resistance to chitosan is related to changes in cell envelope structure of Staphylococcus aureus. Carbohydr Polym. 2017 Feb 10;157:146-155.

32. Mayer G, Schüller A, Matzner D, Lünse C, Wittmann V, Schumacher C, Unsleber S, Brötz-Oesterhelt H, Mayer C, Bierbaum G. Activation of the glmS ribozyme confers bacterial growth inhibition. Chembiochem. 2016 Dec 24.

 

2015

 

1. Katawa G, Layland LE, Debrah AY, von Horn C, Batsa L, Kwarteng A, Arriens S, W
Taylor D, Specht S, Hoerauf A, Adjobimey T. Hyperreactive Onchocerciasis is
Characterized by a Combination of Th17-Th2 Immune Responses and Reduced
Regulatory T Cells.
PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3414. doi:
10.1371/journal.pntd.0003414. eCollection 2015 Jan. PubMed PMID: 25569210.

2. Maffioli SI, Monciardini P, Catacchio B, Mazzetti C, Münch D, Brunati C, Sahl
HG, Donadio S. A family of class I lantibiotics from actinomycetes and
improvement of their antibacterial activities.
ACS Chem Biol. 2015 Jan 9. [Epub
ahead of print] PubMed PMID: 25574687.

3. Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A,
Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR,
Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. A new
antibiotic kills pathogens without detectable resistance.
Nature. 2015 Jan 7.
doi: 10.1038/nature14098. [Epub ahead of print] PubMed PMID: 25561178.

4. Gondorf F, Berbudi A, Buerfent BC, Ajendra J, Bloemker D, Specht S, Schmidt D,
Neumann AL, Layland LE, Hoerauf A, Hübner MP. Chronic Filarial Infection Provides
Protection against Bacterial Sepsis by Functionally Reprogramming Macrophages.

PLoS Pathog. 2015 Jan 22;11(1):e1004616. doi: 10.1371/journal.ppat.1004616.
eCollection 2015 Jan. PubMed PMID: 25611587

5. Mayer K, Hahn-Ast C, Mückter S, Schmitz A, Krause S, Felder L,
Bekeredjian-Ding I, Molitor E, Brossart P, von Lilienfeld-Toal M. Comparison of
antibiotic prophylaxis with cotrimoxazole/colistin (COT/COL) versus ciprofloxacin
(CIP) in patients with acute myeloid leukemia.
Support Care Cancer. 2015 Jan 24.
[Epub ahead of print] PubMed PMID: 25617073.

6. Quintana JF, Makepeace BL, Babayan SA, Ivens A, Pfarr KM, Blaxter M, Debrah A,
Wanji S, Ngangyung HF, Bah GS, Tanya VN, Taylor DW, Hoerauf A, Buck AH.
Extracellular Onchocerca -derived small RNAs in host nodules and blood. Parasit
Vectors.
2015 Jan 27;8(1):58. [Epub ahead of print] PubMed PMID: 25623184.

7. Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB,
Ouellette AJ, Selsted ME, Sahl HG. Killing of staphylococci by θ-defensins
involves membrane impairment and activation of autolytic enzymes.
Antibiotics
(Basel). 2014;3(4):617-631. PubMed PMID: 25632351; PubMed Central PMCID:
PMC4306331.

8. Basi-Chipalu S, Dischinger J, Josten M, Szekat C, Zweynert A, Sahl HG,
Bierbaum G. Pseudomycoicidin, a class II lantibiotic from Bacillus. Appl Environ
Microbiol. 2015 Mar 13. pii: AEM.00299-15. [Epub ahead of print] PubMed PMID:
25769830.

9. Scherer KM, Spille JH, Sahl HG, Grein F, Kubitscheck U. The Lantibiotic Nisin
Induces Lipid II Aggregation, Causing Membrane Instability and Vesicle Budding.

Biophys J. 2015 Mar 10;108(5):1114-24. doi: 10.1016/j.bpj.2015.01.020. PubMed
PMID: 25762323.

10. Wenzel M, Senges CH, Zhang J, Suleman S, Nguyen M, Kumar P, Chiriac AI,
Stepanek JJ, Raatschen N, May C, Krämer U, Sahl HG, Straus SK, Bandow JE.
Antimicrobial Peptides from the Aurein Family Form Ion-Selective Pores in
Bacillus subtilis
. Chembiochem. 2015 Mar 27. doi: 10.1002/PubMed PMID: 25821129

11. Otten C, De Benedetti S, Gaballah A, Bühl H, Klöckner A, Brauner J, Sahl HG,
Henrichfreise B. Co-Solvents as Stabilizing Agents during Heterologous
Overexpression in Escherichia coli - Application to Chlamydial Penicillin-Binding
Protein 6
. PLoS One. 2015 Apr 7;10(4):e0122110. doi:
10.1371/journal.pone.0122110. eCollection 2015. PubMed PMID: 25849314.

12. Arndts K, Klarmann-Schulz U, Batsa L, Debrah AY, Epp C, Fimmers R, Specht S,
Layland LE, Hoerauf A. Reductions in microfilaridermia by repeated ivermectin
treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals.
Parasit Vectors. 2015 Mar 28;8:184. doi: 10.1186/s13071-015-0786-5. PubMed PMID: 25889652; PubMed Central PMCID: PMC4391604.

13. Schumak B, Klocke K, Kuepper JM, Biswas A, Djie-Maletz A, Limmer A, van
Rooijen N, Mack M, Hoerauf A, Dunay IR. Specific Depletion of Ly6Chi Inflammatory
Monocytes Prevents Immunopathology in Experimental Cerebral Malaria
. PLoS One. 2015 Apr 17;10(4):e0124080. doi: 10.1371/journal.pone.0124080. eCollection 2015. PubMed PMID: 25884830; PubMed Central PMCID: PMC4401438

14. Münch D, Sahl HG. Structural variations of the cell wall precursor Lipid II in
Gram-positive bacteria - impact on binding and efficacy of antimicrobial
peptides.
Biochim Biophys Acta. 2015 Apr 28. pii: S0005-2736(15)00137-6. doi:
10.1016/j.bbamem.2015.04.014. [Epub ahead of print] Review. PubMed PMID:
25934055.

15. Debrah AY, Specht S, Klarmann-Schulz U, Batsa L, Mand S, Marfo-Debrekyei Y,
Fimmers R, Dubben B, Kwarteng A, Osei-Atweneboana M, Boakye D, Ricchiuto A,
Büttner M, Adjei O, Mackenzie CD, Hoerauf A. Doxycycline leads to sterility and
enhanced killing of female Onchocerca volvulus worms in an area with persistent
microfilaridermia after repeated ivermectin treatment - a randomized placebo
controlled double-blind trial.
Clin Infect Dis. 2015 May 6. pii: civ363. [Epub
ahead of print] PubMed PMID: 25948064.

16. Hirschfeld J, Dommisch H, Skora P, Horvath G, Latz E, Hoerauf A, Waller T,
Kawai T, Jepsen S, Deschner J, Bekeredjian-Ding I. Neutrophil extracellular trap
formation in supragingival biofilms.
Int J Med Microbiol. 2015 Apr 20. pii:
S1438-4221(15)00038-7. doi: 10.1016/j.ijmm.2015.04.002. [Epub ahead of print]
PubMed PMID: 25959370.

17. Stanton MC, Mkwanda SZ, Debrah AY, Batsa L, Biritwum NK, Hoerauf A, Cliffe M,
Best A, Molineux A, Kelly-Hope LA. Developing a community-led SMS reporting tool
for the rapid assessment of lymphatic filariasis morbidity burden: case studies
from Malawi and Ghana.
BMC Infect Dis. 2015 May 16;15(1):214. [Epub ahead of
print] PubMed PMID: 25981497.

18.Lutz P, Pfarr K, Nischalke HD, Krämer B, Goeser F, Glässner A, Wolter F,
Kokordelis P, Nattermann J, Sauerbruch T, Hoerauf A, Strassburg CP, Spengler U.
The ratio of calprotectin to total protein as a diagnostic and prognostic marker
for spontaneous bacterial peritonitis in patients with liver cirrhosis and
ascites
. Clin Chem Lab Med. 2015 Jun 2. pii:doi:10.1515/cclm-2015-0284. [Epub ahead of print] PubMed PMID: 26035112

19. Mayer K, Hahn-Ast C, Mückter S, Schmitz A, Krause S, Felder L, Bekeredjian-Ding I, Molitor E, Brossart P, von Lilienfeld-Toal M. Comparison of antibiotic prophylaxis with cotrimoxazole/colistin (COT/COL) versus ciprofloxacin (CIP) in patients with acute myeloid leukemia. Support Care Cancer. 2015 May;23(5):1321-9.

20. Schaumburg F, Idelevich EA, Peters G, Mellmann A, von Eiff C, Becker K; Study
Group. Trends in antimicrobial non-susceptibility in methicillin-resistant
Staphylococcus aureus from Germany (2004-2011)
. Clin Microbiol Infect. 2014
Sep;20(9):O554-7.

21. Berbudi A, Ajendra J, Wardani AP, Hoerauf A, Hübner MP. Parasitic helminths
and their beneficial impact on type 1 and type 2 diabetes
. Diabetes Metab Res
Rev. 2015 Jun 25.

22. Buerfent BC, Gondorf F, Wohlleber D, Schumak B, Hoerauf A, Hübner MP.
Escherichia coli-induced immune paralysis is not exacerbated during chronic
filarial infection.
Immunology. 2015 May;145(1):150-60.

23. Vehreschild MJ, Hamprecht A, Peterson L, Schubert S, Häntschel M, Peter S,
Schafhausen P, Rohde H, Lilienfeld-Toal MV, Bekeredjian-Ding I, Libam J, Hellmich
M, Vehreschild JJ, Cornely OA, Seifert H. A multicentre cohort study on
colonization and infection with ESBL-producing Enterobacteriaceae in high-risk
patients with haematological malignancies
. J Antimicrob Chemother. 2014
Dec;69(12):3387-92.

24. Berscheid A, Francois P, Strittmatter A, Gottschalk G, Schrenzel J, Sass P, Bierbaum G. Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS. J Antimicrob Chemother. 2014 Dec;69(12):3190-8.

25. Layland LE, Ajendra J, Ritter M, Wiszniewsky A, Hoerauf A, Hübner MP.
Development of patent Litomosoides sigmodontis infections in semi-susceptible
C57BL/6 mice in the absence of adaptive immune responses
. Parasit Vectors. 2015
Jul 25;8:396.


26. Lutz P, Berger C, Langhans B, Grünhage F, Appenrodt B, Nattermann J, Lammert
F, Hoerauf A, Sauerbruch T, Strassburg CP, Spengler U, Nischalke HD. A farnesoid
X receptor polymorphism predisposes to spontaneous bacterial peritonitis
. Dig
Liver Dis. 2014 Nov;46(11):1047-50.

27. Josten M, Dischinger J, Szekat C, Reif M, Al-Sabti N, Sahl HG, Parcina M, Bekeredjian-Ding I, Bierbaum G. Identification of agr-positive methicillin-resistant Staphylococcus aureus harbouring the class A mec complex by MALDI-TOF mass spectrometry. Int J Med Microbiol. 2014 Nov;304(8):1018-23.

28. Chiriac AI, Kloss F, Krämer J, Vuong C, Hertweck C, Sahl HG. Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors. J Antimicrob Chemother. 2015 Sep;70(9):2576-88.

29. Schmithausen RM, Kellner SR, Schulze-Geisthoevel SV, Hack S, Engelhart S, Bodenstein I, Al-Sabti N, Reif M, Fimmers R, Körber-Irrgang B, Harlizius J, Hoerauf A, Exner M, Bierbaum G, Petersen B, Bekeredjian-Ding I. Eradication of methicillin-resistant Staphylococcus aureus (MRSA) and Enterobacteriaceae expressing extended-spectrum beta-lactamases (ESBL-E) on a model pig farm. Appl Environ Microbiol. 2015 Sep 4.

30. Cartron ML, England SR, Chiriac AI, Josten M, Turner R, Rauter Y, Hurd A, Sahl
HG, Jones S, Foster SJ. Bactericidal activity of the human skin fatty acid
cis-6-hexadecanoic acid on Staphylococcus aureus
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2014 Jul;58(7):3599-609

31. Sahl HG, Shai Y. Preface: Bacterial resistance to antimicrobial peptides.
Biochim Biophys Acta. 2015 Sep 3.

32. Schmid M, Küchenhoff H, Hoerauf A, Tutz G. A survival tree method for the
analysis of discrete event times in clinical and epidemiological studies
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Med. 2015 Sep 10.

33. Coffeng LE, Stolk WA, Hoerauf A, Habbema D, Bakker R, Hopkins AD, de Vlas SJ.
Elimination of African onchocerciasis: modeling the impact of increasing the
frequency of ivermectin mass treatment.
PLoS One. 2014 Dec 29;9

34. Münch D, Engels I, Müller A, Reder-Christ K, Falkenstein-Paul H, Bierbaum G,
Grein F, Bendas G, Sahl HG, Schneider T. Structural variations of the cell wall
precursor lipid II and their influence on binding and activity of the
lipoglycopeptide antibiotic oritavancin
. Antimicrob Agents Chemother. 2015
Feb;59(2):772-81.

35. Hilmi D, Parcina M, Stollewerk D, Ostrop J, Josten M, Meilaender A, Zaehringer U, Wichelhaus TA, Bierbaum G, Heeg K, Wolz C, Bekeredjian-Ding I. Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates. PLoS One. 2014 May 8;9(5)

36. Lutz P, Krämer B, Kaczmarek DJ, Hübner MP, Langhans B, Appenrodt B, Lammert F, Nattermann J, Hoerauf A, Strassburg CP, Spengler U, Nischalke HD. A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis. Dig Liver Dis. 2015 Sep 28.

37. Schäberle TF, Schmitz A, Zocher G, Schiefer A, Kehraus S, Neu E, Roth M, Vassylyev DG, Stehle T, Bierbaum G, Hoerauf A, Pfarr K, König GM. Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives. J Nat Prod. 2015 Oct 23;78(10):2505-9.

38. Schmithausen RM, Schulze-Geisthoevel SV, Stemmer F, El-Jade M, Reif M, Hack S, Meilaender A, Montabauer G, Fimmers R, Parcina M, Hoerauf A, Exner M, Petersen B, Bierbaum G, Bekeredjian-Ding I. Analysis of Transmission of MRSA and ESBL-E among Pigs and Farm Personnel. PLoS One. 2015 Sep 30;10(9)

39. Reiter-Owona I, Rehkaemper-Schaefer C, Arriens S, Rosenstock P, Pfarr K,
Hoerauf A. Specific K39 antibody response and its persistence after treatment in
patients with imported leishmaniasis.
Parasitol Res. 2015 Oct 28.


40. Bauer JS, Ghequire MG, Nett M, Josten M, Sahl HG, De Mot R, Gross H.
Biosynthetic Origin of the Antibiotic Pseudopyronines A and B in Pseudomonas
putida BW11M1
. Chembiochem. 2015 Oct 28.

41. Klöckner A, Otten C, Derouaux A, Vollmer W, Bühl H, De Benedetti S, Münch D, Josten M, Mölleken K, Sahl HG, Henrichfreise B. AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae. Nat Commun. 2014 Jun 23;5:4201.

42. Hischebeth GT, Randau TM, Molitor E, Wimmer MD, Hoerauf A, Bekeredjian-Ding I, Gravius S. Comparison of bacterial growth in sonication fluid cultures with periprosthetic membranes and with cultures of biopsies for diagnosing periprosthetic joint infection. Diagn Microbiol Infect Dis. 2015 Sep 12

43. Globisch D, Specht S, Pfarr KM, Eubanks LM, Hoerauf A, Janda KD. Litomosoides sigmodontis: A jird urine metabolome study. Bioorg Med Chem Lett. 2015 Dec 15

44. Gölz L, Buerfent BC, Hofmann A, Hübner MP, Rühl H, Fricker N, Schmidt D, Johannes O, Jepsen S, Deschner J, Hoerauf A, Nöthen MM, Schumacher J, Jäger A. Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases. Innate Immun. 2015 Nov 24.

45. Henrich E, Ma Y, Engels I, Münch D, Otten C, Schneider T, Henrichfreise B, Sahl HG, Dötsch V, Bernhard F. Lipid Requirements for the Enzymatic Activity of MraY Translocases and in vitro Reconstitution of Lipid II Synthesis Pathway. J Biol Chem. 2015 Nov 30.

46. Walker M, Specht S, Churcher TS, Hoerauf A, Taylor MJ, Basánez MG. Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness. Clin Infect Dis. 2015 Apr 15.

47. Hischebeth GT, Randau TM, Buhr JK, Wimmer MD, Hoerauf A, Molitor E,Bekeredjian-Ding I, Gravius S. Unyvero i60 implant and tissue infection (ITI)multiplex PCR system in diagnosing periprosthetic joint infection. J Microbiol Methods. 2015 Dec 12.

48. Rodrigo MB, Schulz S, Krupp V, Ritter M, Wiszniewsky K, Arndts K, Tamadaho RS, Endl E, Hoerauf A, Layland LE. Patency of Litomosoides sigmodontis infection depends on TLR4 whereas TLR2 signalling influences filarial-specific CD4(+) T cell responses. Immunology. 2015 Dec 30.

49. Weitzel T, Rosas R, Fica A, Dabanch J, Polanco M, Egana A, Triantafilo V, Pfarr K, Hoerauf A, Reiter-Owona I. Is there a risk of filarial infection during long-term missions in Haiti? Travel Med Infect Dis. 2015 Dec 19.

 

2014

1. Albers A, Sartono E, Wahyuni S, Yazdanbakhsh M, Maizels RM, Klarmann-Schulz U,

Pfarr K, Hoerauf A. Real-time PCR detection of the HhaI tandem DNA repeat in pre-

and post-patent Brugia malayi Infections: a study in indonesian transmigrants.

Parasit Vectors. 2014 Mar 31;7(1):146. doi: 10.1186/1756-3305-7-146. PubMed PMID:

24685183.

 

2. Lentz CS, Halls VS, Hannam JS, Strassel S, Lawrence SH, Jaffe EK, Famulok M,

Hoerauf A, Pfarr KM. wALADin benzimidazoles differentially modulate the function

of porphobilinogen synthase orthologs. J Med Chem. 2014 Mar 27;57(6):2498-510.

doi: 10.1021/jm401785n. Epub 2014 Feb 25. PubMed PMID: 24568185; PubMed Central

PMCID: PMC3983392.

 

3. Arumugam S, Hoerauf A, Pfarr KM. Localization of a filarial phosphate permease

that is up-regulated in response to depletion of essential Wolbachia

endobacteria. Exp Parasitol. 2014 Mar;138:30-9. doi:

10.1016/j.exppara.2014.01.006. Epub 2014 Jan 28. PubMed PMID: 24480589.

 

4. Lutz P, Parcina M, Bekeredjian-Ding I, Hoerauf A, Strassburg CP, Spengler U.

Spontaneous bacterial peritonitis by Pasteurella multocida under treatment with

rifaximin. Infection. 2014 Feb;42(1):175-7. doi: 10.1007/s15010-013-0449-4. Epub

2013 Mar 25. PubMed PMID: 23526308.

 

5. Gentil K, Lentz CS, Rai R, Muhsin M, Kamath AD, Mutluer O, Specht S, Hübner

MP, Hoerauf A. Eotaxin-1 is involved in parasite clearance during chronic

filarial infection. Parasite Immunol. 2014 Feb;36(2):60-77. doi:

10.1111/pim.12079. PubMed PMID: 24112106.

 

6. Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann Schulz U, Mand S, Batsa

L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A.

Immunoepidemiological profiling of onchocerciasis patients reveals associations

with microfilaria loads and ivermectin intake on both individual and community

levels. PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2679. doi:

10.1371/journal.pntd.0002679. eCollection 2014 Feb. PubMed PMID: 24587458; PubMed

Central PMCID: PMC3930501.

 

7.Adjobimey T, Satoguina J, Oldenburg J, Hoerauf A, Layland LE. Co-activation

through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and

induces IL-17 secretion in Treg: B cell co-cultures. Innate Immun. 2014

Jan;20(1):12-23. doi: 10.1177/1753425913479414. Epub 2013 Mar 25. PubMed PMID:

23529856.

 

8. Schäberle TF, Schiefer A, Schmitz A, König GM, Hoerauf A, Pfarr K.

Corallopyronin A - a promising antibiotic for treatment of filariasis. Int J Med

Microbiol. 2014 Jan;304(1):72-8. doi: 10.1016/j.ijmm.2013.08.010. Epub 2013 Sep

4. PubMed PMID: 24079981.

 

9. Taylor MJ, Hoerauf A, Townson S, Slatko BE, Ward SA. Anti-Wolbachia drug

discovery and development: safe macrofilaricides for onchocerciasis and lymphatic

filariasis. Parasitology. 2014 Jan;141(1):119-27. doi: 10.1017/S0031182013001108.

Epub 2013 Jul 18. PubMed PMID: 23866958; PubMed Central PMCID: PMC3884836.

 

10. Lutz P, Parcina M, Bekeredjian-Ding I, Nischalke HD, Nattermann J, Sauerbruch

T, Hoerauf A, Strassburg CP, Spengler U. Impact of rifaximin on the frequency and

characteristics of spontaneous bacterial peritonitis in patients with liver

cirrhosis and ascites. PLoS One. 2014 Apr 8;9(4):e93909. doi:

10.1371/journal.pone.0093909. eCollection 2014. PubMed PMID: 24714550; PubMed

Central PMCID: PMC3979735.

 

11. Ajendra J, Specht S, Neumann AL, Gondorf F, Schmidt D, Gentil K, Hoffmann WH,

Taylor MJ, Hoerauf A, Hübner MP. ST2 deficiency does not impair type 2 immune

responses during chronic filarial infection but leads to an increased

microfilaremia due to an impaired splenic microfilarial clearance. PLoS One. 2014

Mar 24;9(3):e93072. doi: 10.1371/journal.pone.0093072. eCollection 2014. PubMed

PMID: 24663956; PubMed Central PMCID: PMC3963995.

 

12. Lentz CS, Stumpfe D, Bajorath J, Famulok M, Hoerauf A, Pfarr KM. New

chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase

from Wolbachia endobacteria. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5558-62.

doi: 10.1016/j.bmcl.2013.08.052. Epub 2013 Aug 20. PubMed PMID: 24012123.

 

13. Ziegler S, Gartner K, Scheuermann U, Zoeller T, Hantzschmann J, Over B,

Foermer S, Heeg K, Bekeredjian-Ding I. Ca(2+) -related signaling events influence

TLR9-induced IL-10 secretion in human B cells. Eur J Immunol. 2014

May;44(5):1285-98. doi: 10.1002/eji.201343994. Epub 2014 Feb 19. PubMed PMID:

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14. Bröker BM, Holtfreter S, Bekeredjian-Ding I. Immune control of Staphylococcus

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Med Microbiol. 2014 Mar;304(2):204-14. doi: 10.1016/j.ijmm.2013.11.008. Epub 2013

Dec 1. PubMed PMID: 24462009.

 

15. Hilmi D, Parcina M, Stollewerk D, Ostrop J, Josten M, Meilaender A, Zaehringer

U, Wichelhaus TA, Bierbaum G, Heeg K, Wolz C, Bekeredjian-Ding I. Heterogeneity

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16. Stockdreher Y, Sturm M, Josten M, Sahl HG, Dobler N, Zigann R, Dahl C. New

Proteins Involved in Sulfur Trafficking in the Cytoplasm of Allochromatium

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Epub 2014 Mar 19. PubMed PMID: 24648525; PubMed Central PMCID: PMC4007435.

 

17. Münch D, Müller A, Schneider T, Kohl B, Wenzel M, Bandow JE, Maffioli S, Sosio

M, Donadio S, Wimmer R, Sahl HG. The Lantibiotic NAI-107 Binds to

Bactoprenol-bound Cell Wall Precursors and Impairs Membrane Functions. J Biol

Chem. 2014 Apr 25;289(17):12063-76. doi: 10.1074/jbc.M113.537449. Epub 2014 Mar

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18. Wenzel M, Chiriac AI, Otto A, Zweytick D, May C, Schumacher C, Gust R, Albada

HB, Penkova M, Krämer U, Erdmann R, Metzler-Nolte N, Straus SK, Bremer E, Becher

D, Brötz-Oesterhelt H, Sahl HG, Bandow JE. Small cationic antimicrobial peptides

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8;111(14):E1409-18. doi: 10.1073/pnas.1319900111. Epub 2014 Mar 24. PubMed PMID:

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19. Cartron ML, England SR, Chiriac AI, Josten M, Turner R, Rauter Y, Hurd A, Sahl

HG, Jones S, Foster SJ. Analysis of the Bactericidal Activity of the Human Skin

Fatty Acid, Cis-6-Hexadecanoic Acid on Staphylococcus aureus. Antimicrob Agents

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20. Schmidt Y, van der Voort M, Crüsemann M, Piel J, Josten M, Sahl HG, Miess H,

Raaijmakers JM, Gross H. Biosynthetic origin of the antibiotic cyclocarbamate

brabantamide A (SB-253514) in plant-associated Pseudomonas. Chembiochem. 2014 Jan

24;15(2):259-66. PubMed PMID: 24436210.

 

21. De Benedetti S, Bühl H, Gaballah A, Klöckner A, Otten C, Schneider T, Sahl HG,

Henrichfreise B. Characterization of serine hydroxymethyltransferase GlyA as a

potential source of D-alanine in Chlamydia pneumoniae. Front Cell Infect

Microbiol. 2014 Feb 26;4:19. doi: 10.3389/fcimb.2014.00019. eCollection 2014.

PubMed PMID: 24616885; PubMed Central PMCID: PMC3935232.

 

22. Bierbaum G, Sahl HG. The search for new anti-infective drugs: untapped

resources and strategies. Int J Med Microbiol. 2014 Jan;304(1):1-2. doi:

10.1016/j.ijmm.2013.10.003. Epub 2013 Oct 11. PubMed PMID: 24183099.

 

23. Wilmes M, Sahl HG. Defensin-based anti-infective strategies. Int J Med

Microbiol. 2014 Jan;304(1):93-9. doi: 10.1016/j.ijmm.2013.08.007. Epub 2013 Sep

4. PubMed PMID: 24119539.

 

24. Dischinger J, Basi Chipalu S, Bierbaum G. Lantibiotics: promising candidates

for future applications in health care. Int J Med Microbiol. 2014

Jan;304(1):51-62. doi: 10.1016/j.ijmm.2013.09.003. Epub 2013 Sep 4. PubMed PMID:

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25. Bekeredjian-Ding I, Greil J, Ammann S, Parcina M. Plasmacytoid Dendritic
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26. Hischebeth GT, Keil VC, Gentil K, Boström A, Kuchelmeister K, Bekeredjian-Ding
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27. Schreiber F, Szekat C, Josten M, Sahl HG, Bierbaum G. Antibiotic-induced
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28. Hancock RE, Sahl HG. New strategies and compounds for anti-infective
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Curr Opin Microbiol. 2013 Oct;16(5):519-21. doi:
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29. Klöckner A, Otten C, Derouaux A, Vollmer W, Bühl H, De Benedetti S, Münch D,
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30. Ziegler S, Bekeredjian-Ding I. In vitro analysis of nucleic Acid recognition
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31. Hischebeth GT, Wimmer MD, Molitor E, Seifert H, Gravius S, Bekeredjian-Ding I.
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32. Ziegler S, Eberle ME, Wölfle SJ, Heeg K, Bekeredjian-Ding I. Bifunctional
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Nucleic Acid Ther. 2013 Dec;23(6):427-34. doi: 10.1089/nat.2013.0447.
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33. Lutz P, Berger C, Langhans B, Grünhage F, Appenrodt B, Nattermann J, Lammert
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34. Koch DC, Schmidt TH, Sahl HG, Kubitscheck U, Kandt C. Structural dynamics of
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35. Liu LJ, Stockdreher Y, Koch T, Sun ST, Fan Z, Josten M, Sahl HG, Wang Q, Luo
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36. Josten M, Dischinger J, Szekat C, Reif M, Al-Sabti N, Sahl HG, Parcina M,
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37. Acosta-Jamett G, Weitzel T, Boufana B, Adones C, Bahamonde A, Abarca K, Craig
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38. Hischebeth GT, Kohlhof H, Wimmer MD, Randau TM, Bekeredjian-Ding I, Gravius S.
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39. Ritter M, Straubinger K, Schmidt S, Busch DH, Hagner S, Garn H, Prazeres da
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40. Schwartz C, Oeser K, Prazeres da Costa C, Layland LE, Voehringer D. T
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41. Straubinger K, Paul S, Prazeres da Costa O, Ritter M, Buch T, Busch DH,
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42. Holzscheiter M, Layland LE, Loffredo-Verde E, Mair K, Vogelmann R, Langer R,
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44.  Lentz CS, Sattler JM, Fendler M, Gottwalt S, Halls VS, Strassel S, Arriens S,
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45. Essig A, Hofmann D, Münch D, Gayathri S, Künzler M, Kallio PT, Sahl HG, Wider
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46. Münch D, Engels I, Müller A, Reder-Christ K, Falkenstein-Paul H, Bierbaum G,
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47. Buerfent BC, Gondorf F, Wohlleber D, Schumak B, Hoerauf A, Hübner MP. E.
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48. Walker M, Specht S, Churcher TS, Hoerauf A, Taylor MJ, Basáñez MG. The
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49. Coffeng LE, Stolk WA, Hoerauf A, Habbema D, Bakker R, Hopkins AD, de Vlas SJ.
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50. Johnston KL, Ford L, Umareddy I, Townson S, Specht S, Pfarr K, Hoerauf A,
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51. Faulde, M., Rutenfranz, M., Hepke, J., Rogge, M., Görner, A., Keth, A. (2014): Human tick infestation pattern, tick-bite rate and associated Borrelia burgdorferi s.l.-infection risk during occupational tick exposure at the Seedorf military training area, northwestern Germany. Ticks and Tick-Borne Diseases 5(5), 594-599.
DOI: 10.1016/j.ttbdis.2014.04.009.

52. Faulde, M., Freise, J. (2014): Gesundheitsschädlinge: Arthropoden und Nagetiere als Krankheitsverursacher sowie Überträger und Reservoire von Krankheitserregern. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz 57(5), 495-503. DOI 10.1007/s00103-013-1919-7.

53. Klasen, J., Faulde, M. (2014): Editorial - Von Ratten, Wanzen und Mücken: „Siedlungsungeziefer“ und Vektoren spielen in Deutschland eine wieder wichtiger werdende Rolle. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz 57(5), 493-494. DOI 10.1007/s00103-014-1944-1.

54. Faulde, M.K., Rueda, L.P., and Bouh A. Khaireh, B.A. (2014): First record of the Asian malaria vector, Anopheles stephensi and its possible role in resurgence of malaria in Djibouti, Horn of Africa. Acta Tropica 139, 39-43.
DOI: 10.1016/j.actatropica.2014.06.016.

 

 

 

2013 - 2009

 

  1. Josten M, Reif M, Szekat C, Al-Sabti N, Roemer T, Sparbier K, Kostrzewa M, Rohde H, Sahl HG, Bierbaum G. Analysis of the MALDI-TOF mass spectrum of Staphylococcus aureus identifies mutations which allow differentiation of the main clonal lineages. 2013.  J Clin Microbiol. epub.
  2. Over B, Ziegler S, Foermer S, Weber AN, Bode KA, Heeg K, Bekeredjian-Ding I. IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B. 2013. Eur J Immunol. epub.
  3. Vollmer J, Schiefer A, Schneider T, Jülicher K, Johnston KL, Taylor MJ, Sahl HG, Hoerauf A, Pfarr K. Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes. 2013. Int J Med Microbiol. epub.
  4. Lentz CS, Halls V, Hannam JS, Niebel B, Strübing U, Mayer G, Hoerauf A, Famulok M, Pfarr KM. A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro. 2013. Chem Biol. 20(2):177-87.
  5. Globisch D, Moreno AY, Hixon MS, Nunes AA, Denery JR, Specht S, Hoerauf A, Janda KD. Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness. 2013. Proc Natl Acad Sci U S A. epub.
  6. Mehnaz S, Saleem RS, Yameen B, Pianet I, Schnakenburg G, Pietraszkiewicz H, Valeriote F, Josten M, Sahl HG, Franzblau SG, Gross H. Lahorenoic Acids A-C, ortho-Dialkyl-Substituted Aromatic Acids from the Biocontrol Strain Pseudomonas aurantiaca PB-St2. 2013. J Nat Prod. epub.
  7. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. 2013. Nat Prod Rep. 30(1):108-60.
  8. Hilmi D, Parcina M, Bode K, Ostrop J, Schuett S, Heeg K, Ziebuhr W, Sommerburg O, Bekeredjian-Ding I. Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction. 2013. Int J Med Microbiol. epub.
  9. Parcina M, Miranda-Garcia MA, Durlanik S, Ziegler S, Over B, Georg P, Foermer S, Ammann S, Hilmi D, Weber KJ, Schiller M, Heeg K, Schneider-Brachert W, Götz F, Bekeredjian-Ding I. Pathogen-Triggered Activation of Plasmacytoid Dendritic Cells Induces IL-10-Producing B Cells in Response to Staphylococcus aureus. 2013. J Immunol. epub.
  10. Doster A, Ziegler S, Foermer S, Rieker RJ, Heeg K, Bekeredjian-Ding I. PTO-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for TLR9 in receptor revision. 2013. Immunology. epub.
  11. Bekeredjian-Ding I. B cell encounters with apoptotic cells. 2012. Autoimmunity. epub.
  12. Hübner MP, Killoran KE, Rajnik M, Wilson S, Yim KC, Torrero MN, Morris CP, Nikonenko B, Blanco JCG, Hemming VG, Mitre E. Chronic Helminth Infection Does Not Exacerbate Mycobacterium Tuberculosis Infection. 2012;e1970.
  13. Bayer AS, Schneider T, Sahl HG. Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall. 2012. Ann N Y Acad Sci. epub.
  14. Albada HB, Chiriac AI, Wenzel M, Penkova M, Bandow JE, Sahl HG, Metzler-Nolte N. Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups. 2012. Beilstein J Org Chem 8:1753-64.
  15. Koyama N, Tokura Y, Münch D, Sahl HG, Schneider T, Shibagaki Y, Ikeda H, Tomoda H. The Nonantibiotic Small Molecule Cyslabdan Enhances the Potency of β-Lactams against MRSA by Inhibiting Pentaglycine Interpeptide Bridge Synthesis. 2012. PLoS One 7(11):e48981.
  16. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. 2012. Nat Prod Rep epub
  17. Schulte B, Bierbaum G, Pohl K, Goerke C, Wolz C. Diversification of clonal complex 5 MRSA strains (Rhine-Hesse clone) within Germany. 2012. J Clin Microbiol. epub
  18. Kindrachuk J, Jenssen H, Elliott M, Nijnik A, Magrangeas-Janot L, Pasupuleti M, Thorson L, Ma S, Easton DM, Bains M, Finlay B, Breukink EJ, Sahl HG, Hancock RE. Manipulation of innate immunity by a bacterial secreted peptide: Lantibiotic nisin Z is selectively immunomodulatory. 2012. Innate Immun. epub
  19. Oeemig JS, Lynggaard C, Knudsen DH, Hansen FT, Noergaard KD, Schneider T, Vad BS, Sandvang D, Nielsen LA, Neve S, Kristensen HH, Sahl HG, Otzen DE, Wimmer R. Eurocin, a new fungal defensin: structure, lipid binding and its mode of action. 2012. J Biol Chem. PMID: 23093408. epub
  20. Fehr EM, Spoerl S, Heyder P, Herrmann M, Bekeredjian-Ding I, Blank N, Lorenz HM, Schiller M. Apoptotic-cell-derived membrane vesicles induce an alternative maturation of human dendritic cells which is disturbed in SLE. 2012. J Autoimmun. pii: S0896-8411(12)00123-0. doi: 10.1016/j.jaut.2012.08.003. epub
  21. Picart Faiget P, Pirtilaa AM, Raventos D, Kristensen HH, Sahl HG. Identification of defensin-encoding genes of Picea glauca: characterization of PgD5, a conserved spruce defensin with strong antifungal activity. BMC Plant Biol. 12(1):180.
  22. Freeman MF, Gurgui C, Helf MJ, Morinaka BI, Uria AR, Oldham NJ, Sahl HG, Matsunaga S, Piel J. Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides. 2012. Science. 338(6105):387-90.
  23. Roos C, Zocher M, Müller D, Münch D, Schneider T, Sahl HG, Scholz F, Wachtveitl J, Ma Y, Proverbio D, Henrich E, Dötsch V, Bernhard F. Characterization of co-translationally formed nanodisc complexes with small multidrug transporters, proteorhodopsin and with the E. coli MraY translocase. 2012. Biochim Biophys Acta. 1818(12):3098-3106.
  24. Georg P, Bekeredjian-Ding I. Plasmacytoid dendritic cells control B cell-derived IL-10 production. 2012. Autoimmunity. epub
  25. Wenzel M, Kohl B, Münch D, Raatschen N, Albada HB, Hamoen L, Metzler-Nolte N, Sahl HG, Bandow JE. Proteomic response of Bacillus subtilis to lantibiotics reflects differences in interaction with the cytoplasmic membrane. 2012. Antimicrob Agents Chemother. epub
  26. Larson D, Cooper PJ, Hübner MP, Reyes J, Vaca M, Chico M, Kong HH, Mitre E. Helminth infection is associated with decreased basophil responsiveness in human beings. 2012. J Allergy Clin Immunol. 130(1):270-2.
  27. Larson D, Hübner MP, Torrero MN, Morris CP, Brankin A, Swierczewski BE, Davies SJ, Vonakis BM, Mitre E. 2012. Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. J Immunol. 188(9):4188-99.
  28. Ulm H, Wilmes M, Shai Y, Sahl HG. Antimicrobial host defensins - specific antibiotic activities and innate defense modulation. 2012. Front Immunol. 3:249.
  29. Biswas R, Martinez RE, Göhring N, Schlag M, Josten M, Xia G, Hegler F, Gekeler C, Gleske AK, Götz F, Sahl HG, Kappler A, Peschel A. Proton-Binding Capacity of Staphylococcus aureus Wall Teichoic Acid and Its Role in Controlling Autolysin Activity. 2012. PLoS One. 7(7):e41415.
  30. Stockdreher Y, Venceslau SS, Josten M, Sahl HG, Pereira IA, Dahl C. Cytoplasmic Sulfurtransferases in the Purple Sulfur Bacterium Allochromatium vinosum: Evidence for Sulfur Transfer from DsrEFH to DsrC. 2012. PLoS One. 7(7):e40785.
  31. Schiller M, Parcina M, Heyder P, Foermer S, Ostrop J, Leo A, Heeg K, Herrmann M, Lorenz HM, Bekeredjian-Ding I. Induction of Type I IFN Is a Physiological Immune Reaction to Apoptotic Cell-Derived Membrane Microparticles. 2012. J Immunol. 189(4):1747-56
  32. Hussain H, Specht S, Sarite SR, Hoerauf A, Krohn K. New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain. 2012. Eur J Med Chem. 54:936-42.
  33. Gentil K, Hoerauf A, Pearlman E. Differential induction of Th2- and Th1-associated responses by filarial antigens and endosymbiotic Wolbachia in a murine model of river blindness. 2012. Eur J Microbiol Immunol. 2:134-139.
  34. Knezevic J, Pavlinic D, Rose WA, Leifer CA, Bendelja K, Gabrilovac J, Parcina M, Lauc G, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelic J, Dembic Z, Weber AN. Heterozygous carriage of a dysfunctional TLR9 allele affects CPG-oligonucleotide responses in B cells. 2012. J Biol Chem.
  35. Mand S, Debrah AY, Klarmann U, Batsa L, Marfo-Debrekyei Y, Kwarteng A, Specht S, Belda-Domene A, Fimmers R, Taylor M, Adjei O, Hoerauf A. Doxycycline Improves Filarial Lymphedema Independent of Active Filarial Infection: A Randomized Controlled Trial. 2012. Clin Infect Dis.
  36. Bekeredjian-Ding I, Foermer S, Kirschning CJ, Parcina M, Heeg K. Poke weed mitogen requires Toll-like receptor ligands for proliferative activity in human and murine B lymphocytes. 2012. PLoS One. 7(1):e29806.
  37. Schiefer A, Schmitz A, Schäberle TF, Specht S, Lämmer C, Johnston KL, Vassylyev DG, König GM, Hoerauf A, Pfarr K. Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo. 2012. J Infect Dis.
  38. Müller A, Münch D, Schmidt Y, Reder-Christ K, Schiffer G, Bendas G, Gross H, Sahl HG, Schneider T, Brötz-Oesterhelt H. The lipodepsipeptide empedopeptin inhibits cell wall biosynthesis through Ca2+-dependent complex formation with peptidoglycan precursors. 2012. J Biol Chem.
  39. Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A. Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti. 2012. PLoS Negl Trop Dis. 6(4):e1611.
  40. Haas J, Bekeredjian-Ding I, Milkova M, Balint B, Schwarz A, Korporal M, Jarius S, Fritz B, Lorenz HM, Wildemann B. 2011. B cells undergo unique compartmentalized redistribution in multiple sclerosis. J Autoimmun. 37(4):289-99.
  41. Sass P, Berscheid A, Jansen A, Oedenkoven M, Szekat C, Strittmatter A, Gottschalk G, Bierbaum G. 2012. Genome Sequence of Staphylococcus aureus VC40, a Vancomycin- and Daptomycin-Resistant Strain, To Study the Genetics of Development of Resistance to Currently Applied Last-Resort Antibiotics. J Bacteriol. 194(8):2107-8.
  42. Müller A, Ulm H, Reder-Christ K, Sahl HG, Schneider T. 2012. Interaction of Type A Lantibiotics with Undecaprenol-Bound Cell Envelope Precursors. Microb Drug Resist. 18(3):261-70.
  43. Berscheid A, Sass P, Weber-Lassalle K, Cheung AL, Bierbaum G. 2012. Revisiting the genomes of the Staphylococcus aureus strains NCTC 8325 and RN4220. Int J Med Microbiol.
  44. Ziewer S, Hübner MP, Dubben B, Hoffmann WH, Bain O, Martin C, Hoerauf A, Specht S. 2012. Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis. PLoS Negl Trop Dis. 6(3):e1558.
  45. Mischnik A, Zimmermann S, Bekeredjian-Ding I, Egermann M. 2012. Relapse of posttraumatic osteomyelitis due to Clostridium celerecrescens. Infection. 39(5):491-4.
  46. Hübner MP, Shi Y, Torrero MN, Mueller E, Larson D, Soloviova K, Gondorf F, Hoerauf A, Killoran KE, Stocker JT, Davies SJ, Tarbell KV, Mitre E. 2012. Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-β. J Immunol. 188(2):559-68.
  47. Tendongfor N, Wanji S, Ngwa JC, Esum ME, Specht S, Enyong P, Matthaei KI, Hoerauf A. 2012. The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization. Parasit Vectors 5(1):43.
  48. Münch D, Roemer T, Lee SH, Engeser M, Sahl HG, Schneider T. 2012. Identification and in vitro Analysis of the GatD/MurT Enzyme-Complex Catalyzing Lipid II Amidation in Staphylococcus aureus. PLoS Pathog. 8(1):e1002509.
  49. Islam MR, Nishie M, Nagao JI, Zendo T, Keller S, Nakayama J, Kohda D, Sahl HG, Sonomoto K. 2012. Ring A of nukacin ISK-1: a lipid II-binding motif for type-A(II) lantibiotic. J Am Chem Soc.
  50. Mand S, Debrah AY, Klarmann U, Mante S, Kwarteng A, Batsa L, Marfo-Debrekyei Y, Adjei O, Hoerauf A. 2011. The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. Acta Trop. 120 Suppl 1:S23-32.
  51. Kumar S, Singh S, Hinze D, Josten M, Sahl HG, Siepmann M, Walter J. 2012. Phosphorylation of the amyloid-β peptide at serine 8 attenuates its clearance via insulin degrading and angiotensin converting enzymes. J Biol Chem.
  52. Türck M, Bierbaum G. 2012. Purification and Activity Testing of the Full-Length YycFGHI Proteins of Staphylococcus aureus. PLoS One. 7(1):e30403.
  53. Arnusch CJ, Albada HB, van Vaardegem M, Liskamp RM, Sahl HG, Shadkchan Y, Osherov N, Shai Y. 2012. Trivalent Ultrashort Lipopeptides are Potent pH Dependent Antifungal Agents. J Med Chem.
  54. Albers A, Esum ME, Tendongfor N, Enyong P, Klarmann U, Wanji S, Hoerauf A, Pfarr K. 2012. Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host. Parasit Vectors.
  55. Herzner AM, Dischinger J, Szekat C, Josten M, Schmitz S, Yakéléba A, Reinartz R, Jansen A, Sahl HG, Piel J, Bierbaum G. 2011. Expression of the lantibiotic mersacidin in Bacillus amyloliquefaciens FZB42. PLoS One 6(7):e22389.
  56. Schmidt KE, Schumak B, Specht S, Dubben B, Limmer A, Hoerauf A. 2011. Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner. Microbes Infect 13(10):828-36.
  57. Liesenfeld O, Parvanova I, Zerrahn J, Han SJ, Heinrich F, Muñoz M, Kaiser F, Aebischer T, Buch T, Waisman A, Reichmann G, Utermöhlen O, von Stebut E, von Loewenich FD, Bogdan C, Specht S, Saeftel M, Hoerauf A, Mota MM, Könen-Waisman S, Kaufmann SH, Howard JC. 2011. The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. PLoS One 6(6):e20568.
  58. Brattig NW, Racz P, Hoerauf A, Büttner DW. 2011. Strong expression of TGF-beta in human host tissues around subcutaneous Dirofilaria repens. Parasitol Res 108(6):1347-54.
  59. Gaballah A, Kloeckner A, Otten C, Sahl HG, Henrichfreise B. 2011. Functional Analysis of the Cytoskeleton Protein MreB from Chlamydophila pneumoniae. PLoS One 6(10):e25129.
  60. Arnusch CJ, Ulm H, Josten M, Shadkchan Y, Osherov N, Sahl HG, Shai Y. 2011 Ultrashort Peptide Bioconjugates are Exclusively Antifungal Agents and Synergize with Cyclodextrin and Amphotericin B. Antimicrob Agents Chemother. 55(3):1296-302.
  61. Sass P, Josten M, Famulla K, Schiffer G, Sahl HG, Hamoen L, Brötz-Oesterhelt H. 2011. Antibiotic acyldepispeptides activate ClpP peptidase to degrade the cell division protein FtsZ. PNAS 108(42):17474-9.
  62. Specht S, Taylor MD, Hoeve M, Allen JE, Lang R, Hoerauf A. 2012. Over expression of IL-10 by macrophages overcomes resistance to murine filariasis. Exp Parasitol 132(1):90-6.
  63. Debrah AY, Batsa L, Albers A, Mand S, Toliat MR, Nürnberg P, Adjei O, Hoerauf A, Pfarr K. 2011. Transforming growth factor-ß1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis. Hum Immunol. 72(11):1143-8.
  64. Hübner MP, Larson D, Torrero MN, Mueller E, Shi Y, Killoran KE, Mitre E. 2011. Anti-FceR1 antiobdy injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice. Clin Immunol.
  65. Sass P, Josten M, Famulla K, Schiffer G, Sahl HG, Hamoen L, Brötz-Oesterhelt H. 2011. Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Proc Natl Acad Sci USA.
  66. Ma Y, Muench D, Schneider T, Sahl HG, Bouhss A, Ghoshdastider U, Wang J, Doetsch V, Wang X, Bernhard F. 2011. Preparative scale cell-free production and quality optimization of MraY homologues in different expression modes. J Biol Chem.
  67. Reder-Christ K, Schmidt Y, Dörr M, Sahl HG, Josten M, Raaijmakers JM, Gross H, Bendas G. 2012. Model membrane studies for characterization of different antibiotic activities of lipopeptides from Pseudomonas. Biochim Biophys Acta. 1818(3):566-73.
  68. Tamarozzi F, Halliday A, Gentil K, Hoerauf A, Pearlman E, Taylor MJ. 2011. Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis and treatment. Clin Microbiol Rev 23(3):459-468.
  69. Herzner AM, Dischinger J, Szekat C, Josten M, Schmitz S, Yakéléba A, Reinartz R, Jansen A, Sahl HG, Piel J, Bierbaum G. 2011. Expression of the lantibiotic mersacidin in Bacillus amyloliquefaciens FZB42. PLoS One 6(7):e22389.
  70. Hoerauf A, Pfarr K, Mand S, Debrah AY, Specht S. 2011. Filariasis in Africa - treatment challenges and prospects. Clin Microbiol Infect 17(7):977-85.
  71. Heinrich N, Mueller A, Bartmann P, Simon A, Bierbaum G, Engelhart S. 2011. Successful management of an MRSA outbreak in a neonatal intensive care unit. Eur J Clin Microbiol Infect Dis 30(7):909-13.
  72. Wilmes M, Cammue BP, Sahl HG, Thevissen K. 2011. Antbiotic activities of host defense peptides: more to it than lipid bilayer perturbation. Nat Prod Rep 28(8):1350-8.
  73. Teran R, Mitre E, Vaca M, Erazo S, Oviedo G, Hübner MP, Chico ME, Matapallil JJ, Bickle Q, Rodrigues LC, Cooper PJ. 2011. Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response. Clin Immunol 138(3):199-310.
  74. Nagel M, Reuter T, Jansen A, Szekat C, Bierbaum G. 2011. Influence of ciprofloxacin and vancomycin on mutation rate and transposition of IS256 in Staphylococcus aureus. Int J Med Microbiol 301(3):229-36.
  75. Liesenfeld O, Parvanova I, Zerrahn J, Han SJ, Heinrich F, Muñoz M, Kaiser F, Aebischer T, Buch T, Waisman A, Reichmann G, Utermöhlen O, von Stebut E, von Loewenich FD, Bogdan C, Specht S, Saeftel M, Hoerauf A, Mota MM, Könen-Waisman S, Kaufmann SH, Howard JC. 2011. The IFNy-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. PLoS One 6(6):e20568.
  76. Rubinchik E, Schneider T, Elliott M, Scott WR, Pan J, Anklin C, Yang H, Dugourd D, Müller A, Gries K, Straus SK, Sahl HG, Hancock RE. 2011. Mechanism of action and limited cross-resistance of new lipopeptide MX-2401. Antimicrob Agents Chemother 55(6):2743-54.
  77. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Albers A, Specht S, Klarmann U, Pfarr K, Adjei O, Hoerauf A. 2011. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifmapicin plus Doxycycline. J Parasitol Res 2011:201617.
  78. Kusch P, Deininger S, Specht S, Maniako R, Haubrich S, Pommerening T, Lin PK, Hoerauf A, Kaiser A. 2011. In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase. J Parasitol Res 2011:268692.
  79. Schmidt KE, Schumak B, Specht S, Dubben B, Limmer A, Hoerauf A. 2011. Induction of pro-inflammatory mediators in Plasmdoium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner. Microbes Infect 13(10):828-36.
  80. Hussain H, Specht S, Sarite SR, Saeftel M, Hoerauf A, Schulz B, Krohn K. 2011. A new class of phenazines with activity against a chloroquine resistant Plasmodium falciparum strain and antimicrobial activity. J Med Chem 54(13):4913-7.
  81. Brattig NW, Racz P, Hoerauf A. Büttner DW. 2011. Strong expression of TGF-beta in human host tissues around subcutaneous Dirofilaria repens. Parasitol Res 108(6):1347-54.
  82. Elsebai MF, Kehraus S, Lindequist U, Sasse F, Shaaban S, Gütschow M, Josten M, Sahl HG, König GM. 2011. Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale. Org Biomol Chem 9(3):802-8.
  83. Specht S, Frank JK, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Förster I, Kirschning CJ, Martin C, Hoerauf A. 2011. CCL17 controls mast cells for the defense against filarial larval entry. J Immunol 186(8):4845-52.
  84. Hoerauf A. 2010. Microflora, helminths and the immune system - who controls whom? N Engl J Med 363(15):1476-8.
  85. Adjobimey T, Hoerauf A. 2010. Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation. Ann Trop Med Parasitol 104(6):455-64.
  86. Taylor MJ, Hoerauf A, Bockarie M. 2010. Lymphatic filariasis and onchocerciasis. Lancet 376(9747):1175-85.
  87. Niebel B, Lentz C, Pofahl M, Mayer G, Hoerauf A, Pfarr KM, Famulok M. 2010. ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling. Chemistry 16(36):11100-7.
  88. Mand S, Debrah AY, Klarmann U, Mante S, Kwarteng A, Batsa L, Marfo-Debrekyei Y, Adjei O, Hoerauf A. 2010. The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. Acta Trop.
  89. Korten S, Hoerauf A, Kaifi JT, Büttner DW. 2011. Low levels of transforming growth factor-beta (TGF-beta) and reduced suppression of Th2-mediated inflammation in hyperreactive human onchocerciasis. Parasitology 138(1):35-45.
  90. Brattig NW, Tenner-Racz K, Korten S, Hoerauf A, Büttner DW. 2010 Immunohistology of ectopic secondary lymph hfollicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda). Parasitol Res 107(3):657-66.
  91. Appenrodt B, Lehmann LE, Thyssen L, Gentemann M, Rabe C, Molitor E, Trebicka J, Stüber F, Sauerbruch T. 2010. Is detection of bacterial DNA in ascitic fluid of clinical relevance= Eur J Gastroenterol Hepatol 22(12):1487-94.
  92. Specht S, Ruiz DF, Dubben B, Deininger S, Hoerauf A. 2010. Filaria-induced IL-10 suppresses murine cerebral malaria. Microbes Infect 12(8-9):635-42.
  93. Turner JD, Tendongfor N, Esum M, Johnston KL, Langley RS, Ford L, Faragher B, Specht S, Mand S, Hoerauf A, Enyong P, Wanji S, Taylor MJ. 2010. Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled-trial. ÖLoS Negl Trop Dis 4(4):e660.
  94. Portillo JA, Okenka G, Reed E, Subauste A; Van Grol J, Gentil K, Komatsu M, Tanaka K, Landreth G, Levine B, Subauste CS. 2010. The CD40-autophagy pathway is needed for host protection despite IFNy-dependent immunity and CD40 induces autophagy via control of P21 levels. PLoS One 5(12):e14472.
  95. Schmitt P, Wilmes M, Pugnière M, Aumelas A, Bachère E, Sahl HG, Schneider T, Destoumieux-Garzón D. 2010. Insight into invertebrate defensin mechanism of action: oyster defensins inhibit peptidoglycan biosynthesis by binding to lipid II. J Biol Chem 285(38):29208-16.
  96. Strübing U, Lucius R, Hoerauf A, Pfarr KM. 2010. Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes. Int J Parasitol 40(10):1193-202.
  97. Korten S, Kaifi JT, Büttner DW, Hoerauf A. 2010. Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia. Microbes Infect 12(7):555-64.
  98. Wansi JD, Hussain H, Tcho AT, Kouam SF, Specht S, Sarite SR, Hoerauf A, Krohn K. 2010. Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii. Phytother Res 24(5):775-7.
  99. Torrero MN, Hübner MP, Larson D, Karasuyama H, Mitre E. 2010. Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis. J Immunol 185(12):7426-34.
  100. Schneider T, Kruse T, Wimmer R, Wiedemann I, Sas V, Pag U, Jansen A, Nielsen AK, Mygind PH, Raventós DS, Neve S, Ravn B, Bonvin AM, De Maria L, Andersen AS, Gammelgaard LK, Sahl HG, Kristensen HH. 2010. Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II. Science 328(5982):1168-72.
  101. Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S, Tschopp J, Layland LE, Prazeres da Costa C. 2010. Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci USA 107(47):20459-64.
  102. Hübner MP, Torrero MN, Mitre E. 2010. Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures. Vaccine 28(7):1746-57.
  103. Rogosch T, Kerzel S, Sikula L, Gentil K, Liebetruth M, Schlingmann KP, Maier RF, Zemlin M. 2010. Plasma cells and nonplasma B cells express differing IgE repertoires in allergic sensitization. J Immunol 184(9):4947-54.
  104. Liu J, Llius A, Illi S, Layland L, Olek S, von Mutius E, Schaub B. 2010. T regulatory cells in cord blood - FOXP3 demethylation as reliable quantitative marker. PLoS One 5(10):e13267.
  105. Sass V, Schneider T, Wilmes M, Körner C, Tossi A, Novikova N, Shamova O, Sahl HG. 2010. Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci. Infect Immun 78(6):2793-800.
  106. Langhans B, Braunschweiger I, Arndt S, Schulte W, Satoguina J, Layland LE, Vidovic N, Hoerauf A, Oldenburg J, Sauerbruch T, Spengler U. 2010. Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C. Clin Sci (Lond) 119(2):97-109.
  107. Brattig NW, Hoerauf A, Fischer PU, Liebau E, Bandi C, Debrah A, Büttner M, Büttner DW. 2010. Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells. Parasitology 137(5):841-54.
  108. Attout T, Hoerauf A, Dénécé G, Debrah AY, Marfo-Debrekyei Y, Boussinesq M, Wanji S, Martinez V, Mand S, Adjei O, Bain O, Specht S, Martin C. 2009. Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule. PLoS One 4(12):e8234.
  109. Schäberle TF, Goralski E, Neu E, Erol O, Hölzl G, Dörmann P, Bierbaum G, König GM. 2010. Marine myxobacteria as a source of antibiotics - comparison of physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina. Mar Drugs 8(9):2466-79.
  110. Layland LE, Mages J, Loddenkemper C, Hoerauf A, Wagner H, Lang R, da Costa CU. 2010. Pronounced phenotype in activated regulatory T cells during a chronic helminth infection. J Immunol 184(2):713-24.
  111. Schneider T, Sahl HG. 2010. Lipid II and other bactoprenol-bound cell wall precursors as drug targets. Curr Opin Inestig Drugs 11(2):157-64.
  112. Schneider T, Sahl HG. 2010. An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway. Int J Med Microbiol 300(2-3):161-9.
  113. Blavid R, Kusch P, Hauber J, Eschweiler U, Sarite SR, Specht S, Deininger S, Hoerauf A, Kaiser A. 2010. Down-regulation of hypusine biosynthesis in Plasmodium by inhibition of S-adenosyl-methionine-decarboxylase. Amino Acids 38(2):461-9.
  114. Then RL, Sahl HG. 2010. Anti-infective strategies of the future: is there room for species-specific antibacterial agents? Curr Pharm Des 16(5):555-66.
  115. Pfarr KM, Debrah AY, Specht S, Hoerauf A. 2009. Filariasis and lymphoedema. Parasite Immunol 31(11):664-72.
  116. Mand S, Pfarr K, Sahoo PK, Satapathy AK, Specht S, Klarmann U, Debrah AY, Ravindran B, Hoerauf A. 2009. Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. Am J Trop Med Hyg 82(4):702-11.
  117. Prusseit J, Simon M, von der Brelie C, Heep A, Molitor E, Volz S, Simon A. 2009. Epidemiology, prevention and management of ventriculoperitoneal shunt infections in children. Pediatr Neurosurg 45(5):325-36.
  118. Specht S, Brattig N, Büttner M, Büttner DW. 2009. Criteria for the differentiation between yound and old Onchocerca volvulus filariae. Parasitol Res 105(6):1531-8.
  119. Hoerauf A. 2009. Mansonella perstans - the importance of an endosymbiont. N Engl J Med 361(15):1502-4.
  120. Specht S, Hoerauf A, Adjei O, Debrah A, Büttner DW. 2009. Newly acquired Onchocerca volvulus filariae after doxycycline treatment. Parasitol Res 106(1):23-31.
  121. Wanji S. Tendongfor N, Nji T, Esum M, Che JN, Nkwescheu A, Alassa F, Kamnang G, Enyong PA, Taylor MJ, Hoerauf A, Taylor DW. 2009 Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon. Parasit Vectors 2(1):39.
  122. Henrichfreise B, Schiefer A, Schneider T, Nzukou E, Poellinger C, Hoffmann TJ, Johnston KL, Moelleken K, Wiedemann I, Pfarr K, Hoerauf A, Sahl HG. 2009. Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed? Mol Microbiol 73(5):913-23.
  123. Pietiäinen M, François  P, Hyyryläinen HL, Tangomo M, Sass V, Sahl HG, Schrezel J, Kontinen VP. 2009. Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistance. BMC Genomics 10:429.
  124. Hübner MP, Torrero MN, McCall JW, Mitre E. 2009. Litomosoides sigmodontis: a simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds (meriones unguiculatus). Exp Parasitol 123(1):95-8.
  125. Torero MN, Larson D, Hübner MP, Mitre E. 2009. CD200R surface expression as a marker of murine basophil activation. Clin Exp Allergy 39(3):361-9.
  126. Dischinger J, Josten M, Szekat C, Sahl HG, Bierbaum G. 2009. Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13. PLoS One 4(8):e6788.
  127. Hübner MP, Stocker JT, Mitre E. 2009. Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells. Immunol 127(4):512-22.
  128. Brattig NW, Schwohl A, Hoerauf A, Büttner DW. 2009. Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus. Acta Trop 112(2):231-5.
  129. Turner JD, Langley RS, Johnston KL, Gentil K, Ford L, Wu B, Graham M, Sharpley F, Slatko B, Pearlman E, Taylor MJ. 2009. Wolbachia lipoprotein stimulates inate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. J Biol Chem 284(33):22364-78.
  130. Griesbeck AG, Neudörfl J, Hörauf A, Specht S, Raabe A. 2009. Antimalarial peroxide dyads from natural artemisinin and hydroyalkylated 1,2,4-trioxanes. J Med Chem 52(10):3420-3.
  131. Specht S, Wanji S. 2009. New insights into the biology of filarial infections. J Helminthol 83(2):199-202.
  132. Marklein G, Josten M, Klanke U, Müller E, Horré R, Maier T, Wenzel T, Kostrzewa M, Bierbaum G, Hoerauf A, Sahl HG. 2009. Matrix-assisted laser desorption ionization-time of flight mass spectrometry for fast and reliable identification of clinical yeast isolates. J Clin Microbiol 47(9):2912-7.
  133. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Lawson B, Taylor M, Adjei O, Hoerauf A. 2009. Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline. Am J Trop Med Hyg. 80(6):956-63.
  134. Korten S, Büttner DW, Schmetz C, Hoerauf A, Mand S, Brattig N. 2009. The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta). Parasitol Res 105(3):731-41.
  135. Gentil K, Pearlman E. 2009. gamma interferon and interleukin-1 receptor 1 regulate neutrophil recruitment to the corneal stroma in a murine model of Onchocerca volvulus keratitis. Infect Immun 77(4):1606-12.
  136. Antcheva N, Morgera F, Creatti L, Vaccari L, Pag U, Pacor S, Shai Y, Sahl HG, Tossi A. 2009. Artificial beta-defensin based on a minimal defensin template. Biochem J 421(3):435-47.
  137. Reiter-Owona I, Grüner B, Frosch M, Hoerauf A, Kern P, Tappe D. 2009. Serological confirmatory testing of alveolar and cystic echinococcosis in clinical practice: results of a comparative study with commercialized and in-house assays. Clin Lab 55(1-2):41-8.
  138. Böttiger T, Schneider T, Martínez B, Sahl HG, Wiedemann I. 2009. Influence of Ca(2+) ions on the activity of lantibiotics containing a mersacidin-like lipid II binding motif. Appl Environ Microbiol 75(13):4427-34.
  139. Specht S, Hoerauf A. 2009. Filarial parasites in the postgenomic era. Expert Rev Anti Infect Ther 7(2):189-92.
  140. Raafat D, Sahl HG. 2009. Chitosan and its antimicrobial potential - a critical literature survey. Microb Biotechnol 2(2):186-201.
  141. Faulde MK, Hoffmann R, Fazilat KM, Hoerauf A. 2009. Epidemiology of Plasmodium falciparum and P. vivax malaria endemic in northern Afghanistan. J Egypt Soc Parasitol 38(3):679-92.
  142. Appleyard AN, Choi S, Read DM, Lightfoot A, Boakes S, Hoffmann A, Chopra I, Bierbaum G, Rudd BA, Dawson MJ, Cortes J. 2009. Dissecting structural and functional diversity of the lantibiotic mersacidin. Chem Biol 16(5):490-8.
  143. Faulde M, Schrader J, Heyl G, Hoerauf A. 2009. High efficacy of integrated preventive measures against zoonotic cutaneous leishmaniasis in northern Afghanistan, as revealed by Quantified Infection Rates. Acta Trop 110(1):28-34.
  144. Schneider T, Gries K, Josten M, Wiedemann I, Pelzer S, Labischinski H, Sahl HG. 2009. The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate. Antmicrob Agents Chemother 53(4):1610-8.
  145. Taylor MJ, Awadzi K, Basáñez MG, Biritwum N, Boakye D, Boatin B, Bockarie M, Churcher TS, Debrah A, Edwards G, Hoerauf A, Mand S, Matthews G, Osei-Atweneboana M, Prichard RK, Wanji S, Adjei O. 2009. Onchocerciasis Control: Vision for the Future from a Ghanian perspective. Parasit Vectors 2(1):7.
  146. Bierbaum G, Sahl HG. 2009. Lantibiotics: mode of action, biosynthesis and bioengineering. Curr Pharm Biotechnol 10(1):2-18.
  147. Sass P, Bierbaum G. 2009. Native graS mutation supports the susceptibility of Staphylococcus aureus strain SG511 to antimicrobial peptides. Int J Med Microbiol 299(5):313-22.
  148. Fernández Ruiz D, Dubben B, Saeftel M, Endl E, Deininger S, Hoerauf A, Specht S. 2009. Filarial infection induces protection against P. berghei liver stages in mice. Microbes Infect 11(2):172-80.
  149. Hoerauf A, Specht S, Marfo-Debrekyei Y, Büttner M, Debrah AY, Mand S, Batsa L, Brattig N, Konadu P, Bandi C, Fimmers R, Adjei O, Büttner DW. 2009. Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus. Parasitol Res 104(2):437-47.
Date: 
Sunday, April 8, 2018 - 09:00

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