Malaria group 2014 (from left to right: Oezlem Mutluer, Janina Kuepper, Beatrix Schumak, Patricia Korir, Hema Bora)
Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum infection and is ascribed to parasite sequestration and excessive pro-inflammatory immune responses generated by the infected host. Experimental models reproducing neurological features observed in human CM allowed the identification of inflammatory mediators (interferon gamma, TNF alpha and Lymphotoxin alpha) and detrimental CD8 T cells to be key players in experimental CM (ECM) pathology. We are interested in brain inflammatory processes during ECM and immune-regulatory processes that are involved in generation and regulation of pro-inflammatory immune responses in ECM. We investigate inflammatory signalling in the periphery and at the blood brain barrier with the help of transgenic parasites and transgenic mice.
Detailed in vivo and in vitro analyses will broaden our understanding of processes leading to ECM pathology and identify possible target molecules for possible future novel, more efficient therapeutic applications in human CM.
Beatrix Schumak, PhD Group leader bschumak [at] uni-bonn.de Tel. 0228-287-13211
Hema Bora, PhD Post-Doc hema_bora [at| yahoo.co.in
Janina M. Kuepper PhD student jkuepper [at] uni-bonn.de
Patricia Jebett Korir PhD student s6pakori [at] uni-bonn.de
Özlem Mutluer Technician
Bonn Cluster of Excellence „Immunosensation“
BONFOR Program of the Medical Faculty University of Bonn
Former group members
Katrin Klocke -> Karolinska Institutet Stockholm, Sweden
Max Borsche -> University of Lübeck